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MR imaging can show small extraocular muscles in patients with CPEO,which may help to distinguish this disorder from other entities.Since denervated extraocular muscles do not readily atrophy,this MR sign would support a myogenic pathologic substrate for CPEO.Variation in the degree of extraocular muscle atrophy may simply reflect the length of time the mitochondrial defect and ophthalmoplegia have been present. |
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